Coles G A, Jones G R, Crosby D L, Jones J H, McVeigh S
Postgrad Med J. 1972 Jul;48(561):399-404. doi: 10.1136/pgmj.48.561.399.
The incidence and aetiology of hypertension following cadaveric-donor renal transplantation have been investigated in twenty-four patients. Initially, the diastolic blood pressure was persistently above 100 mmHg in 52% of the patients. By 1 month after renal transplantation the incidence had fallen to 17% but it then increased rapidly, so that by 5 months 83% had hypertension. Changes in blood pressure correlated poorly with changes in the dose of prednisone, extracellular fluid volume, exchangeable sodium, creatinine clearance and haemoglobin. The recipient's original diseased kidneys were removed after transplantation in seven patients. The blood pressure fell to normal levels in three, remained unchanged in two and became easier to control with antihypertensive drugs in the other two patients. Measurements of plasma renin concentration were of no value in predicting the response to recipient nephrectomy.
对24例尸体供肾肾移植术后高血压的发病率及病因进行了研究。最初，52%的患者舒张压持续高于100 mmHg。肾移植术后1个月时，发病率降至17%，但随后迅速上升，至5个月时83%的患者出现高血压。血压变化与泼尼松剂量、细胞外液量、可交换钠、肌酐清除率及血红蛋白的变化相关性较差。7例患者在移植术后切除了受体原有的病肾。3例患者血压降至正常水平，2例患者血压无变化，另外2例患者使用抗高血压药物后血压更易控制。血浆肾素浓度测定对预测受体肾切除的反应无价值。
