Hooper B, Whittingham S, Mathews J D, Mackay I R, Curnow D H
Clin Exp Immunol. 1972 Sep;12(1):79-87.
As part of a long term prospective study, sera from 3492 subjects, over 90% of the adult population of the rural Australian town of Busselton, were tested by indirect immunofluorescence for various autoantibodies, and by latex particle agglutination for rheumatoid factor. Autoantibodies were detected in 21·6% of all subjects and the overall prevalence increased with age in both sexes. A dip in the age prevalence curve of autoantibodies amongst subjects aged 75–80 years preceded a terminal sharp rise. The greater prevalence in females, 27·5%, than in males, 13·7%, was accounted for by autoantibodies to nuclei, gastric parietal cells and thyroid epithelial cells; the prevalence of smooth muscle antibody (SMA) and rheumatoid factor (RF) was similar in females and males, and the prevalence of SMA did not increase with age. Thus development of age-sex dependent' autoantibodies, to gastric and thyroid antigens, may have a considerable genetic component, whereas the non age-sex dependent' autoantibodies, SMA and RF, may have a considerable extrinsic component, e.g. infection. Autoantibodies were associated in two groups, a nuclear' group and a thyrogastric' group; these groups were neither positively nor negatively associated, implying independent genetic or other causes for their appearance.
作为一项长期前瞻性研究的一部分，对澳大利亚乡村小镇巴瑟尔顿成年人口90%以上的3492名受试者的血清进行了检测，采用间接免疫荧光法检测各种自身抗体，采用乳胶颗粒凝集法检测类风湿因子。在所有受试者中，21.6%检测到自身抗体，总体患病率在两性中均随年龄增长而增加。在75至80岁的受试者中，自身抗体的年龄患病率曲线先出现下降，随后急剧上升。女性患病率为27.5%，高于男性的13.7%，这是由针对细胞核、胃壁细胞和甲状腺上皮细胞的自身抗体所致；平滑肌抗体（SMA）和类风湿因子（RF）在女性和男性中的患病率相似，且SMA的患病率不随年龄增长而增加。因此，针对胃和甲状腺抗原的“年龄性别依赖性”自身抗体的产生可能有相当大的遗传成分，而“非年龄性别依赖性”自身抗体SMA和RF可能有相当大的外在成分，如感染。自身抗体分为两组，“细胞核”组和“甲状腺胃”组；这两组既无正相关也无负相关，这意味着它们的出现有独立的遗传或其他原因。
