促胰液素对清醒大鼠胃分泌的抑制和刺激作用。
Inhibitory and stimulatory effects of secretin on gastric secretion in conscious rats.
作者信息
Johansson I, Lundell L, Svensson S E
出版信息
Br J Pharmacol. 1972 Sep;46(1):94-100. doi: 10.1111/j.1476-5381.1972.tb06852.x.
Abstract
- The effect of pure secretin on gastrin-induced secretion has been studied in conscious rats with Pavlov or Heidenhain pouches.2. Rapid intravenous injection of secretin did not inhibit a plateau secretion of acid in the Heidenhain pouch, but infusion of the same amount of secretin over two hours inhibited secretion in both Heidenhain and Pavlov pouches.3. A rapid intravenous injection of secretin before the onset of gastrin infusion enhanced the acid secretory response to gastrin in both types of pouches.4. Secretin stimulated pepsin secretion.
摘要
已在具有巴甫洛夫或海登海因小胃的清醒大鼠中研究了纯促胰液素对胃泌素诱导分泌的影响。
快速静脉注射促胰液素并未抑制海登海因小胃中的胃酸平台期分泌，但在两小时内输注相同量的促胰液素可抑制海登海因小胃和巴甫洛夫小胃中的分泌。
在输注胃泌素之前快速静脉注射促胰液素可增强两种类型小胃中对胃泌素的胃酸分泌反应。
促胰液素刺激胃蛋白酶分泌。
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