阿托品对清醒大鼠胃液分泌的抑制作用。
Inhibition of gastric secretion by atropine in conscious rats.
作者信息
Johansson I, Lundell L, Svensson S E
出版信息
J Physiol. 1971 Sep;217(3):723-35. doi: 10.1113/jphysiol.1971.sp009596.
Abstract
- The effect of atropine on acid and pepsin secretion, stimulated by feeding, vagus excitation or infusions of gastrin, histamine and methacholine, was studied in conscious rats provided with a Pavlov or a Heidenhain pouch.2. The acid and pepsin secretion in response to food was substantially suppressed by atropine in the Pavlov pouch.3. The strong stimulatory effect of 2-deoxy-D-glucose on acid and pepsin secretion in the Pavlov pouch was almost abolished by atropine.4. A plateau secretion of acid obtained by infusion of submaximal doses of hog gastrin II, was significantly inhibited by atropine in the Pavlov and the Heidenhain pouch.5. Methacholine-induced acid and pepsin secretion in the denervated Heidenhain pouch was nearly completely inhibited by atropine.6. A plateau secretion of acid evoked by infusing histamine in a near maximal dosage was inhibited by atropine to the same extent as the gastrin-induced secretion in the Pavlov pouch.7. The mode of action of atropine as a gastric secretory inhibitor is discussed.
摘要
在配备有巴甫洛夫或海登海因小胃的清醒大鼠中，研究了阿托品对进食、迷走神经兴奋或注入胃泌素、组胺和乙酰甲胆碱所刺激的胃酸和胃蛋白酶分泌的影响。
在巴甫洛夫小胃中，阿托品可显著抑制因食物引起的胃酸和胃蛋白酶分泌。
阿托品几乎完全消除了2-脱氧-D-葡萄糖对巴甫洛夫小胃中胃酸和胃蛋白酶分泌的强烈刺激作用。
在巴甫洛夫和海登海因小胃中，注入次最大剂量猪胃泌素II所获得的胃酸平台分泌，被阿托品显著抑制。
阿托品几乎完全抑制了去神经支配的海登海因小胃中乙酰甲胆碱诱导的胃酸和胃蛋白酶分泌。
注入接近最大剂量组胺所引起的胃酸平台分泌，被阿托品抑制的程度与巴甫洛夫小胃中胃泌素诱导的分泌相同。
讨论了阿托品作为胃分泌抑制剂的作用方式。
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