Mauguière F, Dalery J, de Villard R, Courjon J
Eur Neurol. 1979;18(2):116-23. doi: 10.1159/000115065.
Transient hyperkinesia was observed in a 16-year-old epileptic and mentally retarded patient after a single intravenous perfusion of diphenylhydantoin (DPH). No clinical signs of DPH intoxication were associated with the movement disorder. Repeated plasma anticonvulsant level determinations never showed toxic concentrations of DPH. Since a few spontaneous episodes of hyperkinesia had been observed before, the DPH intravenous perfusion could have unmasked a preexisting latent movement disorder in our patient. However, neuroradiological investigations failed to demonstrate the existence of any anatomical damage of the basal ganglia, and HVA as well as 5-HIAA levels measured in the CSF with the probenecid technique were within the normal range 2 months after cessation of hyperkinesia. HVA and 5-HIAA levels have also been measured in the CSF during the period with hyperkinesia; the results are discussed with reference to previously published data concerning cerebral monoamine metabolism in drug-treated epileptic patients.
在一名16岁的癫痫和智力发育迟缓患者单次静脉注射苯妥英（DPH）后，观察到短暂性运动亢进。运动障碍未伴有DPH中毒的临床体征。多次血浆抗惊厥药水平测定从未显示出DPH的中毒浓度。由于之前已观察到该患者有几次自发性运动亢进发作，所以静脉注射DPH可能使患者先前存在的潜在运动障碍显现出来。然而，神经放射学检查未能证明基底神经节存在任何解剖学损伤，并且在运动亢进停止2个月后，用丙磺舒技术在脑脊液中测得的高香草酸（HVA）以及5-羟吲哚乙酸（5-HIAA）水平均在正常范围内。在运动亢进期间也在脑脊液中测量了HVA和5-HIAA水平；结合先前发表的有关药物治疗癫痫患者脑单胺代谢的数据对结果进行了讨论。
