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补体在克氏锥虫免疫溶解中的作用。

Role of complement in immune lysis of Trypanosoma cruzi.

作者信息

Anziano D F, Dalmasso A P, Lelchuk R, Vásquez C

出版信息

Infect Immun. 1972 Nov;6(5):860-4. doi: 10.1128/iai.6.5.860-864.1972.

Abstract

Studies were performed on the mechanism of immune lysis of culture forms of Trypanosoma (Schizotrypanum) cruzi. Antibody-mediated lysis is caused by complement, which is activated via the classical pathway. The properdin system is not required. The kinetics of the reaction is similar to that followed by immune lysis of sensitized sheep erythrocytes, as is the concentration of divalent cations required for optimal lysis (0.15 mm Ca(2+) and 0.5 mm Mg(2+)), the occurrence of cell membrane uptake of the complement components C3 and C4, and the development of characteristic ultrastructural modifications on the cell membrane.

摘要

对克氏锥虫(裂殖锥虫)培养形式的免疫溶解机制进行了研究。抗体介导的溶解是由补体引起的,补体通过经典途径被激活。不需要备解素系统。该反应的动力学与致敏绵羊红细胞免疫溶解的动力学相似,最佳溶解所需的二价阳离子浓度(0.15 mM Ca(2+) 和 0.5 mM Mg(2+))、补体成分 C3 和 C4 的细胞膜摄取情况以及细胞膜上特征性超微结构改变的发生情况也相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79bd/422621/a94b88b3cb37/iai00275-0212-a.jpg

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