儿茶酚胺对多形核白细胞杀菌活性的影响。
Effect of catecholamines on the bactericidal activity of polymorphonuclear leukocytes.
作者信息
Qualliotine D, DeChatelet L R, McCall C E, Cooper M R
出版信息
Infect Immun. 1972 Sep;6(3):211-7. doi: 10.1128/iai.6.3.211-217.1972.
Abstract
Epinephrine, norepinephrine, and dihydroxyphenylalanine at 8 mm concentrations prevented iodination of zymosan by intact neutrophils and decarboxylation of l-alanine by leukocyte sonic extracts. The same concentration of epinephrine also reduced bactericidal activity of the leukocyte against Staphylococcus aureus, Enterobacter cloacae, and Proteus rettgeri without decreasing phagocytosis of bacteria. Spectral studies indicated that epinephrine interferes with the myeloperoxidase-mediated reactions by competing for available H(2)O(2) via its enzymatic oxidation to adrenochrome. These findings support a mechanism in which H(2)O(2) plays an important role in the bactericidal activity of the leukocyte.
摘要
8毫米浓度的肾上腺素、去甲肾上腺素和二羟基苯丙氨酸可阻止完整中性粒细胞对酵母聚糖的碘化作用以及白细胞超声提取物对L-丙氨酸的脱羧作用。相同浓度的肾上腺素还会降低白细胞对金黄色葡萄球菌、阴沟肠杆菌和雷氏变形杆菌的杀菌活性，而不会减少对细菌的吞噬作用。光谱研究表明，肾上腺素通过酶促氧化为肾上腺色素来竞争可用的H(2)O(2)，从而干扰髓过氧化物酶介导的反应。这些发现支持了一种机制，即H(2)O(2)在白细胞的杀菌活性中起重要作用。
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本文引用的文献
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