Moshal M G, Herron M
J Int Med Res. 1979;7(3):231-4. doi: 10.1177/030006057900700311.
Twenty adult Indian patients suffering from the spastic form of irritable colon, i.e. abdominal pain and constipation, were given trimebutine (Mebutin), 2-phenyl, 2-dimethylamino-n-butyl 3, 4, 5-trimethoxybenzoate. Patients were given treatment with 200 mg trimebutine three times daily, or placebo for 4 weeks, and then crossed over. In addition, stool transit times were assessed by the single stool transit time (SST) method of Cummings. Results showed a statistical improvement in abdominal pain and constipation with both trimebutine and placebo after 4 weeks, but only with trimebutine after 8 weeks. Single stool transit time was significantly reduced after trimebutine.
二十名患有痉挛型肠易激综合征（即腹痛和便秘）的成年印度患者接受了曲美布汀（美布汀）治疗，曲美布汀的化学名称为2-苯基-2-二甲基氨基正丁基3,4,5-三甲氧基苯甲酸酯。患者接受每日三次、每次200毫克曲美布汀的治疗，或接受安慰剂治疗，为期4周，之后进行交叉治疗。此外，采用卡明斯的单次粪便转运时间（SST）方法评估粪便转运时间。结果显示，4周后曲美布汀和安慰剂治疗组的腹痛和便秘情况均有统计学意义上的改善，但8周后仅曲美布汀组有改善。使用曲美布汀后单次粪便转运时间显著缩短。
