产前乳房内接种对牛乳分泌物的影响。抗体活性及对大肠杆菌肠道感染的保护作用。
The influence of preparturient intramammary vaccination on bovine mamary secretions. Antibody activity and protective value against Escherichia coli enteric infections.
作者信息
Wilson M R
出版信息
Immunology. 1972 Dec;23(6):947-55.
Four cows were each vaccinated in two mammary glands with a live, formalin treated, vaccine. Colostrum and milk samples taken in the first 3–4 days after calving, inhibited multiplication of the vaccine strain of bacteria. There was no bactericidal activity. After 4 days, multiplication was inhibited by milk whey from the vaccinated glands and not by whey from non-vaccinated glands. The difference in multiplication rate of added to whey from the vaccinated and non-vaccinated glands continued for at least 28 days. The antibody causing the multiplication inhibition was specific to the vaccine strain within the limits of serotypes tested. Marked differences in indirect haemagglutinating antibody activity were found between mammary secretions from vaccinated and non-vaccinated glands and were still evident 464 days after vaccination. Gnotobiotic pigs infected with one of the strains used for the preparation of vaccine were protected when fed whey from cows vaccinated with the homologous or heterologous antigens. Whey from non-vaccinated cows gave no protection.
四头奶牛的两个乳腺分别接种了经福尔马林处理的活疫苗。产犊后最初3 - 4天采集的初乳和牛奶样本抑制了疫苗菌株细菌的繁殖。没有杀菌活性。4天后，接种腺体的乳清抑制了细菌繁殖，而未接种腺体的乳清则没有。添加到接种和未接种腺体乳清中的细菌繁殖率差异持续了至少28天。在所测试的血清型范围内，导致繁殖抑制的抗体对疫苗菌株具有特异性。接种和未接种腺体的乳腺分泌物之间的间接血凝抗体活性存在显著差异，并且在接种后464天仍然明显。用制备疫苗所用的其中一种菌株感染的无菌猪，在喂食接种了同源或异源抗原的奶牛的乳清后受到了保护。未接种奶牛的乳清没有提供保护作用。
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