Burcharth F, Stage J G, Stadil F, Jensen L I, Fischermann K
Gastroenterology. 1979 Sep;77(3):444-50.
Gastrinomas were localized by concurrent blood sampling in the hepatic vein and portal vein tributaries in 10 of 12 Zollinger-Ellison patients. In one patient, the portal vein could not be catheterized; in the other, a gastrin gradient could not be picked up in either of two examinations. Six of the patients were subsequently operated upon: 5 had pancreatoduodenal resection and 1 had laparotomy at which metastases were found. Four of the resections were probably curative as the patients have done well without treatment since with concentrations of gastrin in serum near zero. The observation period ranges from 17 to 20 mo. It is concluded that transhepatic catheterization of the hepatic vein and portal vein tributaries with blood sampling for gastrin determination permit the verification of the Zollinger-Ellison diagnosis and the localization of the gastrinomas. The latter may lead to the selection of a curative operative treatment in some of the patients.
在12例佐林格 - 埃利森综合征患者中，有10例通过同时采集肝静脉和门静脉分支的血液样本对胃泌素瘤进行了定位。1例患者无法对门静脉进行插管；另1例患者在两次检查中均未检测到胃泌素梯度。随后，6例患者接受了手术：5例行胰十二指肠切除术，1例行剖腹手术，术中发现转移灶。4例切除手术可能达到了治愈效果，因为这些患者术后情况良好，血清胃泌素浓度接近零，此后无需治疗。观察期为17至20个月。结论是，经肝穿刺肝静脉和门静脉分支并采集血液样本测定胃泌素，有助于佐林格 - 埃利森综合征的诊断及胃泌素瘤的定位。后者可能使部分患者能够选择治愈性手术治疗。
