Smith R F, Bettge C L, Dayton S L, Jorgensen J H
Appl Microbiol. 1973 Jan;25(1):15-20. doi: 10.1128/am.25.1.15-20.1973.
A one-year study on an endemic strain of Staphylococcus aureus phage type 84/85 in a children's burn unit is described. The endemic strain rapidly colonized the burns and nares of acute patients after admission but was not isolated from a patient on admission. Nonendemic strains of S. aureus found on some new patients were mostly non-phage typable and did not prevail in burns. The endemic strain was rarely isolated from the nares and skin of reconstructive patients or from the nares of hospital personnel. The endemic strain did colonize the oral cavity, normal skin, and intestinal tract of some acute patients. Endemic and nonendemic strains of S. aureus from the burned children were compared in their biochemical activities and antibiotic sensitivities to two groups of S. aureus from one other local and one Danish burns unit. The latter groups of strains represented different combinations of staphylococcal phage group III strains. Each of the four groups of strains differed in production of hemolysins, Tween 80 hydrolysis, egg yolk reaction, and proteolysis of casein and gelatin. All of the strains were uniformly sensitive to gentamicin, oxacillin, and cephalothin. Only 4 of 162 strains tested were methicillin resistant. The endemic S. aureus strains of phage type 84/85 were uniformly resistant to eight other antibiotics including lincomycin and clindamycin. The endemic strain was not the known cause of a clinically documented infection in a group of 82 acute patients studied. The possible role of S. aureus strains of phage group III in burn grafting problems is discussed.
本文描述了在一家儿童烧伤病房对金黄色葡萄球菌84/85型地方流行菌株进行的为期一年的研究。该地方流行菌株在急性患者入院后迅速定植于烧伤部位和鼻腔，但入院时未从患者身上分离到。在一些新患者身上发现的非地方流行的金黄色葡萄球菌菌株大多无法进行噬菌体分型，且在烧伤部位未占优势。该地方流行菌株很少从重建患者的鼻腔和皮肤或医院工作人员的鼻腔中分离到。该地方流行菌株确实定植于一些急性患者的口腔、正常皮肤和肠道。将烧伤儿童的地方流行和非地方流行金黄色葡萄球菌菌株在生化活性和抗生素敏感性方面与来自另一家本地烧伤病房和一家丹麦烧伤病房的两组金黄色葡萄球菌进行了比较。后两组菌株代表葡萄球菌噬菌体III组菌株的不同组合。四组菌株在溶血素产生、吐温80水解、蛋黄反应以及酪蛋白和明胶的蛋白水解方面均存在差异。所有菌株对庆大霉素、苯唑西林和头孢噻吩均一致敏感。在162株测试菌株中，只有4株对甲氧西林耐药。84/85型地方流行金黄色葡萄球菌菌株对包括林可霉素和克林霉素在内的其他八种抗生素均一致耐药。在研究的82例急性患者中，该地方流行菌株并非临床记录感染的已知病因。文中讨论了噬菌体III组金黄色葡萄球菌菌株在烧伤植皮问题中可能发挥的作用。
