金黄色葡萄球菌的噬菌体类型及抗生素敏感性
Bacteriophage types and antibiotic susceptibility of Staphylococcus aureus.
作者信息
Klastersky J, Beumer J, Daneau D
出版信息
Appl Microbiol. 1971 Dec;22(6):1000-7. doi: 10.1128/am.22.6.1000-1007.1971.
Abstract
In vitro tests of 132 strains of Staphylococcus aureus, among which were 38 (28.7%) heteroresistant strains, were performed with 14 commonly used antibiotics, including gentamicin and vancomycin. Heteroresistant strains were found predominantly, but not only, with group 3 phage-typable strains; no heteroresistant strain was found in out-patients. Gentamicin appeared as a uniformly effective agent at low concentrations against oxacillin-sensitive and -resistant strains. It is suggested that gentamicin should be compared to vancomycin in future clinical therapeutic trials in severe staphylococcal infections, especially in cases due to oxacillin-resistant strains.
摘要
对132株金黄色葡萄球菌进行了体外试验，其中38株（28.7%）为异质性耐药菌株，试验使用了14种常用抗生素，包括庆大霉素和万古霉素。异质性耐药菌株主要在3型噬菌体分型菌株中发现，但并非仅见于此类菌株；门诊患者中未发现异质性耐药菌株。庆大霉素在低浓度时对苯唑西林敏感和耐药菌株均表现出一致的有效性。建议在未来严重葡萄球菌感染的临床治疗试验中，尤其是由苯唑西林耐药菌株引起的病例中，将庆大霉素与万古霉素进行比较。
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