小鼠巨噬细胞对同基因和异基因红细胞的细胞毒性作用。
The cytotoxic effect of mouse macrophages on syngeneic and allogeneic erythrocytes.
作者信息
Melsom H, Seljelid R
出版信息
J Exp Med. 1973 Mar 1;137(3):807-20. doi: 10.1084/jem.137.3.807.
Abstract
A cytotoxic effect of mouse peritoneal macrophages against syngeneic and allogeneic erythrocytes was demonstrated by isotope release and release of hemoglobin. The cytotoxic effect was dependent on the contact between viable, activated macrophages and target cells. Activation was accomplished by prolonged cultivation of macrophages and by the presence of Zn(++) and Con-A. Immunization did not prove necessary. Morphological observations as well as experiments with various salt concentrations indicate that the cytotoxic reaction may involve some kind of osmotic effect upon the target cells.
摘要
通过同位素释放和血红蛋白释放，证明了小鼠腹腔巨噬细胞对同基因和异基因红细胞具有细胞毒性作用。细胞毒性作用取决于存活的、活化的巨噬细胞与靶细胞之间的接触。活化是通过巨噬细胞的长时间培养以及锌离子（Zn++）和刀豆球蛋白A（Con-A）的存在来实现的。免疫并非必要条件。形态学观察以及不同盐浓度的实验表明，细胞毒性反应可能涉及对靶细胞的某种渗透作用。
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本文引用的文献
1
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J Exp Med. 1965 Jan 1;121(1):153-70. doi: 10.1084/jem.121.1.153.
2
PHYTOHAEMAGGLUTININ-INDUCED CYTOTOXIC ACTION OF NORMAL LYMPHOID CELLS ON CELLS IN TISSUE CULTURE.植物血凝素诱导的正常淋巴细胞对组织培养细胞的细胞毒作用
Nature. 1964 Aug 22;203:841-3. doi: 10.1038/203841a0.
3
HOMOGRAFT TARGET CELLS: SPECIFIC DESTRUCTION IN VITRO BY CONTACT INTERACTION WITH IMMUNE MACROPHAGES.同种移植靶细胞：通过与免疫巨噬细胞的接触相互作用在体外特异性破坏
Science. 1964 Sep 25;145(3639):1427-9. doi: 10.1126/science.145.3639.1427.
4
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J Cell Biol. 1968 Jul;38(1):244-8. doi: 10.1083/jcb.38.1.244.
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6
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Exp Cell Res. 1970 Jul;61(1):229-30. doi: 10.1016/0014-4827(70)90284-3.
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