布罗克辛在帕金森病中的作用。一种外周和中枢脱羧酶抑制剂增强左旋多巴的作用。
Brocresine in Parkinson's disease. Action of a peripheral and central decarboxylase inhibitor in potentiating levodopa.
作者信息
Howse P M, Matthews W B
出版信息
J Neurol Neurosurg Psychiatry. 1973 Feb;36(1):27-9. doi: 10.1136/jnnp.36.1.27.
Abstract
Brocresine, an aromatic L-amino acid decarboxylase inhibitor with both a peripheral and central action was shown to potentiate the therapeutic effect of levodopa in Parkinson's disease. The search for useful decarboxylase inhibitors therefore need not be limited to agents that do not pass the blood/brain barrier.
摘要
溴克辛是一种具有外周和中枢作用的芳香族L-氨基酸脱羧酶抑制剂，已证明它能增强左旋多巴对帕金森病的治疗效果。因此，寻找有用的脱羧酶抑制剂不必局限于不能通过血脑屏障的药物。
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Int J Neuropharmacol. 1964 May;3:177-88. doi: 10.1016/0028-3908(64)90006-1.
2
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Acta Physiol Scand. 1958 Dec 15;44(3-4):293-8. doi: 10.1111/j.1748-1716.1958.tb01628.x.
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Acta Physiol Scand. 1958 Dec 15;44(3-4):273-92. doi: 10.1111/j.1748-1716.1958.tb01627.x.
4
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Rev Neurol (Paris). 1970 Nov;123(5):297-319.
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