左旋多巴联合脑外多巴脱羧酶抑制剂L-α-甲基多巴肼治疗帕金森病。
Treatment of Parkinson's disease with levodopa combined with L-alpha-methyldopahydrazine, an inhibitor of extracerebral DOPA decarboxylase.
作者信息
Marsden C D, Barry P E, Parkes J D, Zilkha K J
出版信息
J Neurol Neurosurg Psychiatry. 1973 Feb;36(1):10-4. doi: 10.1136/jnnp.36.1.10.
Abstract
Thirty patients with Parkinson's disease were treated for four weeks with levodopa combined with an inhibitor of extracerebral dopa decarboxylase, L-alpha-methyldopahydrazine (MK 486). The therapeutic results were compared with the effects of treatment of a group of 40 patients with levodopa alone. Patients treated with the combined therapy improved more rapidly, had less nausea and vomiting, and required a much smaller dose of levodopa than patients treated with levodopa by itself.
摘要
30名帕金森病患者接受了左旋多巴与脑外多巴脱羧酶抑制剂L-α-甲基多巴肼（MK 486）联合治疗四周。将治疗结果与40名单独使用左旋多巴治疗的患者的疗效进行了比较。联合治疗的患者改善更快，恶心和呕吐更少，并且与单独使用左旋多巴治疗的患者相比，所需的左旋多巴剂量要小得多。
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Idiopathic Parkinsonism treated with an extracerebral decarboxylase inhibitor in combination with levodopa.用脑外脱羧酶抑制剂与左旋多巴联合治疗特发性帕金森病。
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