Sultzer B M
Infect Immun. 1972 Jan;5(1):107-13. doi: 10.1128/iai.5.1.107-113.1972.
Two pathophysiological effects of endotoxin in mice have been shown to be under the major influence of polygenic inheritance. The first, endotoxemia, was measured by LD(50) assays on hybrids and backcross hybrids of the resistant C(3)H/HeJ and the susceptible A/HJe strains. The LD(50) values of the F1 hybrids and the backcross hybrids were intermediate between the respective parental types. The second effect, the intraperitoneal extravascular leukocyte response to small doses of endotoxin, also was found to follow characteristic patterns of polygenic inheritance. As estimated from an analysis of the variance of mice of the F1 and F2 generations, the degree of genetic determination is approximately 54% for the neutrophil response and 82% for the monuclear response.
内毒素对小鼠的两种病理生理效应已被证明主要受多基因遗传的影响。第一种效应是内毒素血症，通过对耐药的C(3)H/HeJ品系和易感的A/HJe品系的杂种及回交杂种进行半数致死剂量（LD(50)）测定来衡量。F1杂种和回交杂种的LD(50)值介于各自亲本类型之间。第二种效应是小剂量内毒素引起的腹腔血管外白细胞反应，也被发现遵循多基因遗传的特征模式。根据对F1和F2代小鼠方差分析的估计，中性粒细胞反应的遗传决定程度约为54%，单核细胞反应的遗传决定程度约为82%。
