Nordenson I, Salmonsson S, Brun E, Beckman G
Hum Genet. 1979 Apr 17;48(1):1-6. doi: 10.1007/BF00273266.
A significantly increased frequency of chromosomal aberrations was found in lymphocytes from eight psoriatic patients previously treated with arsenic than in lymphocytes from eight psoriatics with no such previous treatment. In most patients the arsenic therapy was discontinued more than 15 years ago. In the arsenic-treated group a statistically significant heterogeneity was found with respect to the frequency of aberrations. The frequency of sister chromatid exchange was not increased in the arsenic-treated patients.
在8名曾接受过砷治疗的银屑病患者的淋巴细胞中，发现染色体畸变的频率显著高于8名未接受过此类治疗的银屑病患者的淋巴细胞。在大多数患者中，砷治疗在15年多以前就已停止。在接受过砷治疗的组中，发现畸变频率存在统计学上的显著异质性。接受过砷治疗的患者中姐妹染色单体交换频率并未增加。
