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Elevated sister chromatid exchange rate in lymphocytes of subjects treated with arsenic.

作者信息

Burgdorf W, Kurvink K, Cervenka J

出版信息

Hum Genet. 1977 Apr 7;36(1):69-72. doi: 10.1007/BF00390438.

DOI:10.1007/BF00390438
PMID:870411
Abstract

An elevated sister chromatid exchange (SCE) rate was found in the lymphocytes of six patients treated with arsenic. All had stigmata of arsenic use as well as biopsy-proven skin cancers. The arsenic exposed patients had a mean of 14.00 SCE/mitosis while 44 normal controls had a mean of 5.8 SCE/mitosis. Chromosome breakage analysis revealed no difference between the two groups. SCE rate has been shown to be elevated in a variety of systems where cell cultures or experimental animals were exposed to known mutagens and carcinogens. We suggest that the relationship carcinogen exposure-elevated SCE rate-cancer may also be valid in humans treated with arsenic.

摘要

相似文献

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引用本文的文献

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本文引用的文献

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Cancer Res. 1965 Aug;25(7):980-5.
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Chromosome studies on lymphocytes of patients under cytostatic therapy. II. Studies Using the BUDR-labelling technique in cytostatic interval therapy.细胞抑制疗法下患者淋巴细胞的染色体研究。II. 细胞抑制间歇疗法中使用溴脱氧尿苷标记技术的研究。
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7
Arsenic elevates the sister chromatid exchange (SCE) rate in human lymphocytes in vitro.砷在体外可提高人淋巴细胞中的姐妹染色单体交换（SCE）率。
Arch Dermatol Res. 1980;267(1):91-5. doi: 10.1007/BF00416927.
8
Investigation of the sister chromatid exchange (SCE) frequency in one patient with xeroderma pigmentosum.对一名着色性干皮病患者的姐妹染色单体交换（SCE）频率的研究。
Arch Dermatol Res. 1981;271(4):407-9. doi: 10.1007/BF00406685.
9
Baseline and sodium arsenite-induced sister chromatid exchanges in cultured lymphocytes from patients with Blackfoot disease and healthy persons.乌脚病患者和健康人培养淋巴细胞的基线及亚砷酸钠诱导的姐妹染色单体交换
Hum Genet. 1981;59(3):201-3. doi: 10.1007/BF00283663.
10
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Hum Genet. 1981;58(2):198-203. doi: 10.1007/BF00278711.
4
Giemsa technique for the detection of sister chromatid exchanges.用于检测姐妹染色单体交换的吉姆萨技术。
Chromosoma. 1974;48(4):355-60. doi: 10.1007/BF00290992.
5
A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.布卢姆综合征淋巴细胞中姐妹染色单体交换的多重增加。
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4508-12. doi: 10.1073/pnas.71.11.4508.
6
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7
Differential chromatid staining by in vivo treatment as a mutagenicity test system.将体内处理作为一种致突变性测试系统的差异染色单体染色法。
Nature. 1976 Apr 1;260(5550):448-9. doi: 10.1038/260448a0.
8
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J Med Genet. 1977 Aug;14(4):256-7. doi: 10.1136/jmg.14.4.256.
9
Sister chromatid exchange in xeroderma pigmentosum cells that are defective in DNA excision repair or post-replication repair.在DNA切除修复或复制后修复存在缺陷的着色性干皮病细胞中的姐妹染色单体交换。
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