通过与具有交叉反应性的大肠杆菌进行胃肠道定植诱导新生兔产生 b 型流感嗜血杆菌荚膜抗体。
Induction of Haemophilus influenzae type b capsular antibody in neonatal rabbits by gastrointestinal colonization with cross-reacting Escherichia coli.
作者信息
Myerowitz R L, Handzel Z T, Scheerson R, Robbins J B
出版信息
Infect Immun. 1973 Feb;7(2):137-40. doi: 10.1128/iai.7.2.137-140.1973.
Abstract
In two separate experiments, newborn rabbits were fed a live suspension of either of two Escherichia coli strains which possess a "K" antigen cross-reactive with the capsular polysaccharide of Haemophilus influenzae type b. Both feedings were harmless and resulted in fecal excretion of the fed E. coli in most animals as well as active immunization of fed animals toward H. influenzae type b. Feeding non-enteropathogenic, cross-reacting E coli to newborns may be a method for inducing active immunity toward H. influenzae type b diseases by accelerating the acquisition of "natural" immunity.
摘要
在两项独立实验中，给新生兔喂食两种大肠杆菌菌株之一的活悬液，这两种菌株具有与b型流感嗜血杆菌荚膜多糖交叉反应的“K”抗原。两次喂食均无害，大多数动物的粪便中都排出了所喂食的大肠杆菌，并且所喂食的动物对b型流感嗜血杆菌产生了主动免疫。给新生儿喂食非致病性、交叉反应性大肠杆菌可能是一种通过加速“自然”免疫的获得来诱导对b型流感嗜血杆菌疾病产生主动免疫的方法。
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