通过ACAC血液灌流去除酚类物质的体外评估。

In-vitro assessment of the removal of phenols by ACAC hemoperfusion.

作者信息

Kaziuka E N, Chang T M

出版信息

Int J Artif Organs. 1979 Jul;2(4):215-21.

Abstract

The in-vitro removal of free phenols by means of perfusion over albumin coated cellulose nitrate microencapsulated activated charcoal (ACAC) was studied. The phenols tested were in the form of a standard solution comprised of phenol, p-cresol, and p-hydroxyphenylacetic acid in a ratio of 1:5:14. Four different activated charcoals were tested for their adsorption capacity. Further studies were conducted to determine; the effect of microencapsulation and albumin coating of the activated charcoal on the adsorption of phenols; the adsorption isotherm of phenols; the capacity; and the clearance values. The results obtained suggest that ACAC used in the management of patients with uremia or hepatic coma is extremely efficient in removing phenols in aqueous solution in the in-vitro situation.

摘要

研究了通过在白蛋白包被的硝酸纤维素微囊化活性炭（ACAC）上灌注来体外去除游离酚的方法。所测试的酚为标准溶液形式，由苯酚、对甲酚和对羟基苯乙酸按1:5:14的比例组成。测试了四种不同的活性炭的吸附能力。进行了进一步的研究以确定；活性炭的微囊化和白蛋白包被对酚吸附的影响；酚的吸附等温线；容量；以及清除率值。所得结果表明，用于尿毒症或肝昏迷患者治疗的ACAC在体外情况下去除水溶液中的酚非常有效。