Chang T M, Chirito E, Barre P, Cole C, Lister C, Resurreccion E
J Dial. 1977;1(3):239-59. doi: 10.3109/08860227709039147.
A total of 30 procedures have been carried out in two patients using a new portable, compact, dialysate-free system formed by combining 300 gms of albumin--cellulose nitrate microencapsulated activated charcoal (ACAC) in series with a small Amicon ultrafiltrator. Blood passing through the ACAC hemoperfusion system is purified of waste metabolites and toxins. Fluid removal is carried out with the hydrostatic pressure of the blood passing through the dialysate-free ultrafiltrator. Since ACAC hemoperfusion is much more efficient than hemodialysers for blood purification, the combined system with the ultrafiltrator results in a very efficient system for blood purification and fluid removal. Typical clearance data for the combined systems include: 75 ml/min for 2000--5000 MW; 112.7 ml/min for 300--1500 MW; 235 ml/min for creatinine; 240 ml/min for uric acid; 2500--2700 ml/2 hours for water removal; and 17--18 gm/2 hours for NaCl removal. Guanidines, mercaptans, and PTH are also cleared very efficiently.
使用一种新型便携式、紧凑型、无透析液系统，已对两名患者进行了总共30次操作。该系统由300克硝酸纤维素微囊化活性炭（ACAC）与小型Amicon超滤器串联组成。流经ACAC血液灌流系统的血液中的废物代谢产物和毒素被清除。通过无透析液超滤器利用血液的静水压进行液体清除。由于ACAC血液灌流在血液净化方面比血液透析器效率更高，因此带有超滤器的组合系统形成了一个非常高效的血液净化和液体清除系统。该组合系统的典型清除数据包括：分子量2000 - 5000的物质清除率为75毫升/分钟；分子量300 - 1500的物质清除率为112.7毫升/分钟；肌酐清除率为235毫升/分钟；尿酸清除率为240毫升/分钟；两小时内水清除量为2500 - 2700毫升；两小时内氯化钠清除量为17 - 18克。胍类、硫醇类和甲状旁腺激素也能被非常有效地清除。
