胃抑制多肽在十二指肠和空肠中的细胞定位。

Polak J M, Bloom S R, Kuzio M, Brown J C, Pearse A G

Gut. 1973 Apr;14(4):284-8. doi: 10.1136/gut.14.4.284.

Indirect immunofluorescence studies using an antiserum to purified porcine gastric inhibitory polypeptide indicate, in the gastrointestinal tract of dog and man, that this polypeptide is present in cells situated predominantly in the mid-zone of the glands in the duodenum and, to a lesser extent, in the jejunum. Absolute correlation of the gastric inhibitory polypeptide cell with one or other of the known endocrine-like cells identified by electron microscopy awaits confirmation by electron immunocytochemistry. It is here identified as an endocrine polypeptide cell of the APUD series and, provisionally, as the D(1) cell. While the hormonal status of a given polypeptide depends ultimately on physiological experiments the present results strengthen the view that gastric inhibitory polypeptide is indeed a hormone.

使用抗纯化猪胃抑制性多肽抗血清进行的间接免疫荧光研究表明，在狗和人的胃肠道中，这种多肽存在于主要位于十二指肠腺中区的细胞中，在空肠中的含量较少。胃抑制性多肽细胞与通过电子显微镜鉴定的一种或其他已知类内分泌细胞的绝对相关性有待电子免疫细胞化学证实。在此将其鉴定为APUD系列的内分泌多肽细胞，并暂时鉴定为D(1)细胞。虽然特定多肽的激素状态最终取决于生理学实验，但目前的结果强化了胃抑制性多肽确实是一种激素的观点。