肺容积对人体侧支通气及气道阻力的影响。

Effects of lung volume on collateral and airways resistance in man.

作者信息

Inners C R, Terry P B, Traystman R J, Menkes H A

出版信息

J Appl Physiol Respir Environ Exerc Physiol. 1979 Jan;46(1):67-73. doi: 10.1152/jappl.1979.46.1.67.

DOI:10.1152/jappl.1979.46.1.67

Abstract

The effects of changing lung volume (VL) on collateral resistance (Rcoll) and total airways resistance (Raw) were compared in six young volunteers. At functional residual capacity (FRC) = 55% total lung capacity (TLC), mean Rcoll was 4,664 +/- 1,518 (SE) cmH2O/(l/s) and mean Raw was 1.57 +/- 0.11 (SE) cmH2O/l/s). When VL increased to 80% TLC, Rcoll decreased by 63.3 +/- 7.8%, and Raw decreased by 50.3 +/- 4.2 (SE) %. The decrease in Rcoll with increasing lung volume was not statistically different from that of Raw (P less than 0.05). If the airways obstructed for measurements of Rcoll served between 2 and 5% of the lungs, then Rcoll was approximately 50 times as great as the resistance to flow through airways serving the same volume of lung at FRC. The relationship did not change significantly when VL increased by 25% TLC. If changes in Raw reflect changes in airways supplying sublobar portions of lung, these results indicate that there is no tendency for the redistribution of ventilation through airways and collateral pathways with changes in VL in young subjects.

摘要

在6名年轻志愿者中比较了肺容积（VL）变化对侧支阻力（Rcoll）和总气道阻力（Raw）的影响。在功能残气量（FRC）=肺总量（TLC）的55%时，平均Rcoll为4664±1518（标准误）cmH₂O/（l/s），平均Raw为1.57±0.11（标准误）cmH₂O/l/s。当VL增加到TLC的80%时，Rcoll下降了63.3±7.8%，Raw下降了50.3±4.2（标准误）%。Rcoll随肺容积增加的下降与Raw的下降在统计学上无差异（P<0.05）。如果用于测量Rcoll的阻塞气道占肺的2%至5%，那么Rcoll大约是在FRC时流经相同肺容积气道的气流阻力的50倍。当VL增加TLC的25%时，这种关系没有显著变化。如果Raw的变化反映了供应肺叶下部分气道的变化，这些结果表明，在年轻受试者中，随着VL的变化，通气不会通过气道和侧支途径重新分布。