Armstrong R B, Marum P, Tullson P, Saubert C W
J Appl Physiol Respir Environ Exerc Physiol. 1979 Apr;46(4):835-42. doi: 10.1152/jappl.1979.46.4.835.
The purpose of this project was to study the initial rapid enlargement phase of skeletal muscle in response to ablation of synergistic muscles. The first experiment tested the hypothesis that this initial phase is due to inflammation in the enlarging muscle. The wet weight of the plantaris muscle increased significantly (14%) within 1 h after removal of the ipsilateral gastrocnemius muscle. This increase was due to inflammation, as evidenced initially by edema, and within the next few hours, by leukocyte invasion of the interstitium and enhanced hexose monophosphate shunt-reducing capacity. In the second experiment we followed the time course of this inflammatory reaction. The response peaked at 1-5 days following surgery, after which it subsided to control levels by 16 days postsurgery. The final experiments were designed to uncover the factor(s) causing the inflammatory response. Two possible mechanisms were hypothesized: 1) trauma resulting from surgical manipulation of the tissue, and 2) trauma due to elevated stretch and/or tension on the muscle following removal of the synergists. The data indicate that surgical trauma is the causative factor of the inflammatory response in this hypertrophy model.
本项目的目的是研究骨骼肌在协同肌切除后最初的快速增大阶段。第一个实验检验了这样一个假设，即这个初始阶段是由于增大的肌肉发生炎症所致。在切除同侧腓肠肌后1小时内，比目鱼肌的湿重显著增加（14%）。这种增加是由炎症引起的，最初表现为水肿，在接下来的几个小时内，表现为白细胞侵入间质以及磷酸己糖旁路还原能力增强。在第二个实验中，我们跟踪了这种炎症反应的时间进程。反应在手术后1 - 5天达到峰值，之后在术后16天恢复到对照水平。最后的实验旨在揭示引起炎症反应的因素。提出了两种可能的机制：1）组织手术操作导致的创伤，以及2）协同肌切除后肌肉上拉伸和/或张力升高导致的创伤。数据表明手术创伤是这个肥大模型中炎症反应的致病因素。
