麻疹病毒对培养细胞的持续感染。3. 人宫颈癌细胞系（HeLa细胞）原发性持续感染中合成的病毒特异性RNA的比较
Persistent infection of cells in culture by measles virus. 3. Comparison of virus-specific RNA synthesized in primary persistent infection in HeLa cells.
作者信息
Winston S H, Rustigian R, Bratt M A
出版信息
J Virol. 1973 Jun;11(6):926-32. doi: 10.1128/JVI.11.6.926-932.1973.
Abstract
The pattern of actinomycin D-resistant RNA synthesis was examined during primary infection of HeLa cells by virulent Edmonston measles virus and in two HeLa clones persistently infected by the same strain of virus. One of these clones, K11, produces infectious virus of low virulence for HeLa cells, and the other, K11A-HG-1, has thus far failed to yield infectious virus. The patterns of virus-specific RNA synthesized in these three types of infection are qualitatively similar to each other and to the patterns of virus-specific RNA synthesis in other paramyxovirus infections. There were, however, quantitative differences. In addition, virions of the virulent Edmonston strain of measles virus were found to contain high-molecular-weight RNA with a sedimentation constant identical to that of Newcastle disease virus.
摘要
在强毒株埃德蒙斯顿麻疹病毒对HeLa细胞的初次感染期间，以及在两个被同一毒株病毒持续感染的HeLa细胞克隆中，研究了放线菌素D抗性RNA合成的模式。其中一个克隆K11产生对HeLa细胞低毒力的传染性病毒，另一个克隆K11A-HG-1迄今未能产生传染性病毒。在这三种感染类型中合成的病毒特异性RNA模式在质量上彼此相似，并且与其他副粘病毒感染中的病毒特异性RNA合成模式相似。然而，存在数量上的差异。此外，发现麻疹病毒强毒株埃德蒙斯顿株的病毒粒子含有沉降常数与新城疫病毒相同的高分子量RNA。
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本文引用的文献
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A carrier state in HeLa cells with measles virus (Edmonston strain) apparently associated with non-infectious virus.在HeLa细胞中存在一种与麻疹病毒（埃德蒙斯顿株）相关的携带状态，这种状态显然与非感染性病毒有关。
Virology. 1962 Jan;16:101-4. doi: 10.1016/0042-6822(62)90212-x.
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Growth of measles virus in KB cells.麻疹病毒在KB细胞中的生长。
Virology. 1962 May;17:157-63. doi: 10.1016/0042-6822(62)90092-2.
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Clonal growth of mammalian cells in vitro; growth characteristics of colonies from single HeLa cells with and without a feeder layer.哺乳动物细胞的体外克隆生长；有无饲养层时单个海拉细胞形成的集落的生长特性。
J Exp Med. 1956 Feb 1;103(2):273-83. doi: 10.1084/jem.103.2.273.
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J Mol Biol. 1966 Jun;18(1):204-14. doi: 10.1016/s0022-2836(66)80086-4.
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RNA synthesis in chick embryo cells infected with different strains of NDV.感染不同新城疫病毒毒株的鸡胚细胞中的RNA合成
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