通过寡核苷酸指纹图谱对麻疹病毒RNA进行比较分析。
A comparative analysis of measles virus RNA by oligonucleotide fingerprinting.
作者信息
Stephenson J R, ter Meulen V
出版信息
Arch Virol. 1982;71(4):279-90. doi: 10.1007/BF01315058.
Abstract
Isolates from two cases of acute measles, one case of acute measles encephalitis and three patients with subacute sclerosing panencephalitis were compared. This comparison was based upon the electrophoretic analysis of T1 oligonucleotides from single-stranded, full-length RNA isolated from cytoplasmic nucleocapsids. Although all viruses have oligonucleotides in common, each isolate generated a unique pattern of oligonucleotides. However, no group of oligonucleotides was observed which would allow a differentiation between viruses isolated from acute infections and those isolated from CNS diseases; indicating that probably all measles viruses differ in their nucleotide sequence, regardless of origin.
摘要
对两例急性麻疹、一例急性麻疹脑炎及三名亚急性硬化性全脑炎患者的病毒分离株进行了比较。该比较基于对从细胞质核衣壳分离的单链全长RNA的T1寡核苷酸的电泳分析。虽然所有病毒都有共同的寡核苷酸，但每个分离株都产生了独特的寡核苷酸模式。然而，未观察到能区分急性感染分离的病毒与中枢神经系统疾病分离的病毒的寡核苷酸组；这表明可能所有麻疹病毒的核苷酸序列都不同，无论其来源如何。
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