Porter D D, Larsen A E, Porter H G
Am J Pathol. 1973 May;71(2):331-44.
Mink chronically infected with Aleutian disease virus develop a severe necrotizing arteritis affecting muscular arteries. Acute, subacute and healing lesions may be found. Extracellular deposits of host immunoglobulin and complement and, after acid elution, viral antigen can be shown by immunofluorescence technics in areas of fibrinoid necrosis and between proliferating endothelial cells. No intracellular viral antigen was found, indicating that the virus probably does not replicate in vascular structures. The arteritis of Aleutian disease appears to be the result of immune complex deposits in vessel walls.
长期感染阿留申病病毒的水貂会发生严重的坏死性动脉炎，累及肌性动脉。可发现急性、亚急性和愈合期病变。在纤维蛋白样坏死区域以及增殖的内皮细胞之间，通过免疫荧光技术可显示宿主免疫球蛋白和补体的细胞外沉积物，酸洗脱后还可显示病毒抗原。未发现细胞内病毒抗原，这表明该病毒可能不在血管结构中复制。阿留申病的动脉炎似乎是免疫复合物沉积于血管壁的结果。
