Brauer G M, Kumpula J W, Termini D J, Davidson K M
J Biomed Mater Res. 1979 Jul;13(4):593-606. doi: 10.1002/jbm.820130406.
The durability of the bond strength developed between 2-cyanoacrylate esters and bone has been determined by aging specimens in water. One-day bond strength of the isobutyl and isomeric amyl 2-cyanoacrylates varied from 6.2 to 7.2 MPa. The strength of the bond decreased on storage or on thermocycling in water. Hydrolytic stability increased with increasing length of the alkyl ester group. After a six-month storage in water the various amyl 2-cyanoacrylates retained from 70% to 73% of their one-day bond strength. Pretreatment of the bone surface prior to application of the adhesive did not prove beneficial. The cured 2-cyanoacrylate can be removed from the substrate surface by appropriate solvents. Thus, it is not bonded covalently to bone. The bond strength, especially of the isobutyl and amyl 2-cyanoacrylates to bone in an aqueous environment, appears to be superior to other adhesives. Provided these monomers are biocompatible, they may be useful clinically where an intermediate-term adhesion is desired.
通过在水中老化样本，已确定了2-氰基丙烯酸酯与骨之间形成的粘结强度的耐久性。异丁基和异构戊基2-氰基丙烯酸酯的一日粘结强度在6.2至7.2兆帕之间变化。粘结强度在水中储存或热循环时会降低。水解稳定性随烷基酯基团长度的增加而提高。在水中储存六个月后，各种戊基2-氰基丙烯酸酯保留了其一日粘结强度的70%至73%。在施加粘合剂之前对骨表面进行预处理并未证明有益。固化的2-氰基丙烯酸酯可以通过适当的溶剂从基材表面去除。因此，它不是与骨共价结合的。在水性环境中，粘结强度，尤其是异丁基和戊基2-氰基丙烯酸酯与骨的粘结强度，似乎优于其他粘合剂。如果这些单体具有生物相容性，那么在需要中期粘附的临床应用中它们可能会有用。
