Langman M J, Knapp D R, Wakley E J
Br Med J. 1973 Jul 14;3(5871):84-6. doi: 10.1136/bmj.3.5871.84.
In 68 patients with chronic gastric ulcer treated in an outpatient clinical trial with either carbenoxolone or gefarnate ulcer healing was consistently greater during carbenoxolone treatment, even though the dose of gefarnate was ultimately increased to four times that recommended. One-third of the patients receiving carbenoxolone gained weight rapidly and unexpectedly, and were given diuretic treatment, compared with two of the 35 patients receiving gefarnate, neither of whom developed clinical oedema.
在一项门诊临床试验中，68例慢性胃溃疡患者分别接受甘草次酸或吉法酯治疗。尽管吉法酯的剂量最终增加到推荐剂量的四倍，但在甘草次酸治疗期间溃疡愈合情况始终更好。接受甘草次酸治疗的患者中有三分之一迅速意外地体重增加，并接受了利尿剂治疗，而在接受吉法酯治疗的35例患者中，有2例体重增加，且均未出现临床水肿。
