La Brooy S J, Taylor R H, Hunt R H, Golding P L, Laidlaw J M, Chapman R G, Pounder R E, Vincent S H, Colin-Jones D G, Milton-Thompson G J, Misiewicz J J
Br Med J. 1979 May 19;1(6174):1308-9. doi: 10.1136/bmj.1.6174.1308.
Fifty-four outpatients with endoscopically diagnosed benign gastric ulcer were allocated at random to treatment with either cimetidine 800 mg daily for six weeks or carbenoxolone sodium 300 mg daily for one week then 150 mg daily for five weeks. Ulcers were reassessed by endoscopy at the end of the trial. The endoscopist was unaware of the treatment and did not take part in the clinical care of the patients. Twenty-one of the 27 patients (78%) given cimetidine and 14 of the 27 (52%) given carbenoxolone had healed ulcers. Symptomatic response occurred earlier with cimetidine but was not significantly better. Unwanted effects were more common in the carbenoxolone group: 12 patients developed hypokalaemia, four of whom needed oral potassium supplements. The results suggest that histamine H2-receptor blockade is at least as effective as carbenoxolone sodium for benign gastric ulcer and produces fewer side effects.
54例经内镜诊断为良性胃溃疡的门诊患者被随机分配接受以下治疗：西咪替丁每日800毫克，持续六周；或甘草次酸二钠每日300毫克，持续一周，然后每日150毫克，持续五周。试验结束时通过内镜复查溃疡情况。内镜检查医师不知道治疗情况，也未参与患者的临床护理。接受西咪替丁治疗的27例患者中有21例（78%）溃疡愈合，接受甘草次酸二钠治疗的27例患者中有14例（52%）溃疡愈合。西咪替丁组症状缓解出现得更早，但改善程度无显著差异。甘草次酸二钠组不良反应更常见：12例患者出现低钾血症，其中4例需要口服补钾。结果表明，组胺H2受体阻滞剂治疗良性胃溃疡至少与甘草次酸二钠同样有效，且副作用更少。
