在翻译受到抑制期间大肠杆菌中信使核糖核酸的合成与降解
Messenger ribonucleic acid synthesis and degradation in Escherichia coli during inhibition of translation.
作者信息
Pato M L, Bennett P M, von Meyenburg K
出版信息
J Bacteriol. 1973 Nov;116(2):710-8. doi: 10.1128/jb.116.2.710-718.1973.
Abstract
Various aspects of the coupling between the movement of ribosomes along messenger ribonucleic acids (mRNA) and the synthesis and degradation of mRNA have been investigated. Decreasing the rate of movement of ribosomes along an mRNA does not affect the rate of movement of some, and possibly most, of the RNA polymerases transcribing the gene coding for that mRNA. Inhibiting translation with antibiotics such as chloramphenicol, tetracycline, or fusidic acid protects extant mRNA from degradation, presumably by immobilizing ribosomes, whereas puromycin exposes mRNA to more rapid degradation than normal. The promoter distal (3') portion of mRNA, synthesized after ribosomes have been immobilized by chloramphenicol on the promoter proximal (5') portion of the mRNA, is subsequently degraded.
摘要
核糖体沿信使核糖核酸（mRNA）移动与mRNA合成及降解之间偶联的各个方面已得到研究。降低核糖体沿mRNA的移动速率，并不影响转录该mRNA编码基因的部分RNA聚合酶（可能是大部分）的移动速率。用氯霉素、四环素或夫西地酸等抗生素抑制翻译，大概是通过固定核糖体来保护现存的mRNA不被降解，而嘌呤霉素则使mRNA比正常情况更快地被降解。在核糖体被氯霉素固定在mRNA的启动子近端（5'）部分之后合成的mRNA的启动子远端（3'）部分，随后会被降解。
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