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A mutant of Escherichia coli with a new, highly efficient promoter for the lactose operon.一种具有用于乳糖操纵子的新型高效启动子的大肠杆菌突变体。
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Nat New Biol. 1972 May 10;237(71):47-9. doi: 10.1038/newbio237047a0.

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Mutator gene studies in Escherichia coli: the mutS gene.大肠杆菌中的突变基因研究：mutS基因
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本文引用的文献

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A SECOND PERMEASE FOR METHYL-THIO-BETA-D-GALACTOSIDE IN ESCHERICHIA COLI.大肠杆菌中甲基硫代-β-D-半乳糖苷的第二种通透酶
Biochim Biophys Acta. 1965 May 4;100:591-3. doi: 10.1016/0304-4165(65)90029-2.
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A NONSPECIFIC INCREASE IN PERMEABILITY IN ESCHERICHIA COLI PRODUCED BY EDTA.乙二胺四乙酸（EDTA）导致大肠杆菌通透性非特异性增加。
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RECOMBINATION BETWEEN COLIPHAGES LAMBDA AND PHI-80.大肠杆菌噬菌体λ和φ80之间的重组
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RESTORATION OF OPERON ACTIVITY BY SUPPRESSORS.通过抑制子恢复操纵子活性
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Synthesis and turnover of phage messenger RNA in E. coli infected with bacteriophage T4 in the presence of chloromycetin.在氯霉素存在的情况下，被噬菌体T4感染的大肠杆菌中噬菌体信使RNA的合成与周转
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Transduction by bacteriophage P-1 and the properties of the lac genetic region in E. coli and S. dysenteriae.噬菌体P-1的转导以及大肠杆菌和痢疾志贺氏菌中乳糖基因区域的特性
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Increased stability of polysomes in an Escherichia coli mutant with relaxed control of RNA synthesis.在对RNA合成控制松弛的大肠杆菌突变体中多核糖体稳定性增加。
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Nonsense mutants and polarity in the lac operon of Escherichia coli.大肠杆菌乳糖操纵子中的无义突变体与极性
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A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membrane.一种用于检测固定在膜上的DNA与RNA杂交体的定量分析方法。
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Level of tryptophan messenger RNA in Escherichia coli.大肠杆菌中色氨酸信使核糖核酸的水平
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大肠杆菌中的新型极性抑制子：抑制作用与信使核糖核酸稳定性

New polarity suppressors in Escherichia coli: suppression and messenger RNA stability.

作者信息

Carter T, Newton A

出版信息

Proc Natl Acad Sci U S A. 1971 Dec;68(12):2962-6. doi: 10.1073/pnas.68.12.2962.

DOI:10.1073/pnas.68.12.2962
PMID:4943549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC389570/
Abstract

Two new polarity suppressors (Su27 and Su78) have been isolated in Escherichia coli. Both suppress polarity in the trp and lac operons, and neither shows codon specificity for suppression. Extreme polar mutants of the lac z gene that contain either Su27 or Su78 make mRNA from the entire operon; however, no active beta-galactosidase is translated from the z-gene messenger, and the amount of distal messenger is greater than would be expected from corresponding enzyme activities. Puromycin treatment of lac(+) strains mimics the effect of polar chain-termination mutations in destabilizing lac mRNA. This effect is completely reversed by Su27, and it is partially reversed by Su78. The results suggest that these suppressors act by stabilizing mRNA after premature termination of protein synthesis.

摘要

在大肠杆菌中分离出了两种新的极性抑制因子（Su27和Su78）。它们都能抑制色氨酸和乳糖操纵子中的极性，且都不表现出抑制的密码子特异性。含有Su27或Su78的乳糖z基因的极端极性突变体可从整个操纵子产生信使核糖核酸（mRNA）；然而，z基因信使并未翻译出有活性的β-半乳糖苷酶，并且远端信使的量比相应酶活性预期的要多。用嘌呤霉素处理乳糖（+）菌株，在使乳糖mRNA不稳定方面模拟了极性链终止突变的作用。这种作用被Su27完全逆转，被Su78部分逆转。结果表明，这些抑制因子通过在蛋白质合成过早终止后稳定mRNA而起作用。