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一种意外小鼠同种异型的放射免疫分析。

Radioimmune analysis of an unexpected mouse allotype.

作者信息

DeWitt C L, Bosma M J

出版信息

J Exp Med. 1979 Aug 1;150(2):351-8. doi: 10.1084/jem.150.2.351.

DOI:10.1084/jem.150.2.351
PMID:458378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185619/
Abstract

We have used a radioimmune assay to confirm our earlier findings of an unexpected immunoglobulin allotype in Igb-congenic BALB/c mice. Although these mice were bred to exclude the IgG2a allotype of BALB/c (Ig-la), an Ig-la-like antigen was detected in the 7S Ig fraction of two (of five) pooled serum samples, it represented 0.1--0.3% of the total 7S protein and was indistinguishable from a reference Ig-la. The detection of putative Ig-la in Igb-congenic mice is inconsistent with the notion that allotypes are products of allelic structural genes. It appears rather that expression of Ig-la is controlled by allelic regulator genes and that its low and transient production in Igb-congenic mice results from incomplete negative regulation.

摘要

我们已使用放射免疫测定法来证实我们之前在Igb同基因BALB/c小鼠中发现的一种意外免疫球蛋白同种异型的结果。尽管这些小鼠经过培育以排除BALB/c的IgG2a同种异型（Ig-1a），但在五个合并血清样本中的两个样本的7S Ig组分中检测到了一种类似Ig-1a的抗原，它占总7S蛋白的0.1 - 0.3%，并且与参考Ig-1a无法区分。在Igb同基因小鼠中检测到推定的Ig-1a与同种异型是等位结构基因产物的观点不一致。相反，Ig-1a的表达似乎受等位调节基因控制，并且其在Igb同基因小鼠中的低水平和短暂产生是由于负调节不完全所致。

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本文引用的文献

1
Enzymatically produced subunits of proteins formed by plasma cells in mice. I. gamma-Globulin and gamma-myeloma proteins.小鼠浆细胞产生的蛋白质的酶促亚基。I. γ-球蛋白和γ-骨髓瘤蛋白。
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Active suppression of immunoglobulin allotype synthesis. 3. Identification of T cells as responsible for suppression by cells from spleen, thymus, lymph node, and bone marrow.免疫球蛋白同种异型合成的主动抑制。3. 鉴定T细胞是脾脏、胸腺、淋巴结和骨髓来源细胞抑制作用的原因。
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Immunoglobulin allotypic specificities in mixed leucocyte cultures.混合白细胞培养中的免疫球蛋白同种异型特异性
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Standardization of the chloramine-T method of protein iodination.蛋白质碘化氯胺-T法的标准化
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A rabbit with the allotypic phenotype: ala2a3 b4b5b6.一只具有异型表型的兔子：ala2a3 b4b5b6 。
J Immunol. 1974 Oct;113(4):1313-8.
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Congenic mouse strains: the expression of a hidden immunoglobulin allotype in a congenic partner strain of BALB-c mice.同源近交系小鼠：BALB-c小鼠同源近交系伙伴中隐藏免疫球蛋白同种异型的表达。
J Exp Med. 1974 Mar 1;139(3):512-27. doi: 10.1084/jem.139.3.512.
8
Synthesis of Gm allotypes by human tonsillar lymphocytes in culture: concordance with serum phenotype.人扁桃体淋巴细胞在培养中合成Gm同种异型：与血清表型的一致性。
J Immunol. 1976 Apr;116(4):1045-50.
9
Nonallelic behavior of rabbit variable-region allotypes.兔可变区同种异型的非等位基因行为。
J Exp Med. 1975 Jun 1;141(6):1448-52. doi: 10.1084/jem.141.6.1448.
10
Quantitation of mouse immunoglobulin allotypes by a modified solid-phase radioimmune assay.通过改良的固相放射免疫测定法定量小鼠免疫球蛋白同种异型
J Immunol. 1975 Nov;115(5):1381-6.

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