同源近交系小鼠：BALB-c小鼠同源近交系伙伴中隐藏免疫球蛋白同种异型的表达。
Congenic mouse strains: the expression of a hidden immunoglobulin allotype in a congenic partner strain of BALB-c mice.
作者信息
Bosma M J, Bosma G C
出版信息
J Exp Med. 1974 Mar 1;139(3):512-27. doi: 10.1084/jem.139.3.512.
Abstract
This paper derives from the unexpected observations of the "wrong immunoglobulin allotype" in a congenic partner strain of BALB/c mice from the Institute of Cancer Research (ICR CB-17). These mice were specially bred so as not to differ from BALB/c mice in any known way except to carry immunoglobulin structural genes of the C57BL/Ka allotype. In this respect, ICR CB-17 mice were defined as allotypically homozygous according to the Mendelian inheritance of mouse allotype markers. The homozygosity of these mice was challenged, however, when in certain instances immunoglobulins of the BALB/c allotype appeared in the serum of some ICR CB-17 mice. The appearance of this hidden allotype was usually transient and only associated with immunoglobulins of the IgG (IgG2a) class. The implications of these findings for the inheritance and expression of immunoglobulin structural genes are discussed.
摘要
本文源自对癌症研究所（ICR CB - 17）的BALB/c小鼠同基因伙伴品系中“错误免疫球蛋白同种异型”的意外观察。这些小鼠经过特殊培育，除携带C57BL/Ka同种异型的免疫球蛋白结构基因外，在任何已知方面都与BALB/c小鼠无异。在这方面，根据小鼠同种异型标记的孟德尔遗传，ICR CB - 17小鼠被定义为同种异型纯合子。然而，当某些ICR CB - 17小鼠血清中出现BALB/c同种异型的免疫球蛋白时，这些小鼠的纯合性受到了质疑。这种隐藏同种异型的出现通常是短暂的，且仅与IgG（IgG2a）类免疫球蛋白相关。本文讨论了这些发现对免疫球蛋白结构基因遗传和表达的影响。
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Congenic mouse strains: the expression of a hidden immunoglobulin allotype in a congenic partner strain of BALB-c mice.同源近交系小鼠：BALB-c小鼠同源近交系伙伴中隐藏免疫球蛋白同种异型的表达。
J Exp Med. 1974 Mar 1;139(3):512-27. doi: 10.1084/jem.139.3.512.
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