兔可变区同种异型的非等位基因行为。
Nonallelic behavior of rabbit variable-region allotypes.
作者信息
Mudgett M, Fraser B A, Kindt T J
出版信息
J Exp Med. 1975 Jun 1;141(6):1448-52. doi: 10.1084/jem.141.6.1448.
Abstract
Group a allotypes not detected by qualitative typing or anticipated from breeding data (latent allotypes) were detected at low levels in 50% of normal rabbit sera tested. The latent allotypes, which were serologically identical to allotypes of pooled IgG, were detected in sera from rabbits with all possible combinations of group a allotypes and their occurrence in individual rabbits was transitory and sporadic. These findings give reason to question the assumption that the synthesis of immunoglobulin allotypes is directed by allelic structural genes.
摘要
通过定性分型未检测到或根据繁殖数据未预期到的A组同种异型（潜在同种异型），在50%检测的正常兔血清中低水平存在。这些潜在同种异型在血清学上与混合IgG的同种异型相同，在具有A组同种异型所有可能组合的兔血清中被检测到，并且它们在个体兔中的出现是短暂和零星的。这些发现使人有理由质疑免疫球蛋白同种异型的合成由等位结构基因指导这一假设。
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