Moher L M, Maurer S A
J Fam Pract. 1979 Aug;9(2):237-40.
A case is reported of apparent podophyllum toxicity. The patient was a 17-year-old female Indian who had received some 3 to 8 cc of a 20 percent mixture of podophyllum resin in compound tincture of benzoin (approximately equal to 0.4 gm of podophylotoxin) as an application to her vulvar condylomata. She returned to the hospital 20 hours after application in a comatose state. On examination she demonstrated severe toxicity including bone marrow, liver, and central nervous system. She required a charcoal hemoperfusion at the University of Colorado, and six months after the event has several neurologic and physiologic sequelae. Podophyllum is a potentially severely toxic drug. Great care must be taken when treating patients with this drug. A large mass of condylomata or the status of pregnancy should be relative contraindications to the use of podophyllum.
报告了一例明显的鬼臼毒素中毒病例。患者是一名17岁的印度女性，她外用了约3至8毫升20%鬼臼树脂复方安息香酊剂（约相当于0.4克鬼臼毒素）来治疗外阴湿疣。用药20小时后，她昏迷着回到医院。检查发现她出现了严重中毒症状，累及骨髓、肝脏和中枢神经系统。她在科罗拉多大学接受了活性炭血液灌流治疗，事件发生六个月后仍有多种神经和生理后遗症。鬼臼毒素是一种潜在的剧毒药物。使用该药治疗患者时必须格外小心。大量湿疣或怀孕状态应作为使用鬼臼毒素的相对禁忌证。
