Slater G E, Rumack B H, Peterson R G
Obstet Gynecol. 1978 Jul;52(1):94-6.
The toxicity of topically applied podophyllin in a 16-year-old girl is presented. Coma requiring respiratory support and major neurologic complications as well as hematologic and hepatic toxicity was observed. Therapy with a new modality, charcoal hemoperfusion, resulted in resolution of the acute toxicity, leaving a peripheral neuropathy which had not completely resolved after 4 months. The pharmacology and suggested treatment measures for the toxicity of this rarely reported agent are reviewed.
本文报告了一名16岁女孩局部应用鬼臼树脂后的毒性反应。观察到其出现需要呼吸支持的昏迷、严重的神经系统并发症以及血液学和肝脏毒性。采用一种新的治疗方式——活性炭血液灌流进行治疗，使急性毒性反应得到缓解，但遗留了周围神经病变，4个月后仍未完全恢复。本文对这种罕见报道药物的毒性的药理学及建议治疗措施进行了综述。
