鬼臼树脂自行用于阴茎尖锐湿疣。

Self-application of podophyllin resin for penile condylomata acuminata.

作者信息

Lim K B, Lee C T, Koh Y L, Yeo W L, Tan T

出版信息

Ann Acad Med Singap. 1987 Jan;16(1):167-9.

Abstract

Two methods of podophyllin application, namely hospital-application (regimen A) and self-application (regimen B) of 25% podophyllin in tincture of benzoin compound for the treatment of penile condylomata were compared. The objective was to compare the response and safety of self-application with traditional hospital-application. A total of 100 men were selected, of which 64 were valid for evaluation of response. At six weeks' follow-up 66% and 72% of patients treated with regimen A and B, respectively were cured. Patients treated with regimen A were less compliant making only 58% of the required number of applications as compared with those treated with regimen B who made 92% of the applications. Of the patients successfully treated, 43% and 20% of those treated with regimens A and B, respectively were cured after only one or two applications (p greater than 0.1). Three patients--two treated with regimen A and one treated with regimen B suffered local reactions to the first application of podophyllin. All these patients recovered without sequelae. Self-application of podophyllin can therefore be used safely and effectively in selected men with penile condyloma acuminata.

摘要

比较了两种鬼臼树脂的应用方法，即使用复方安息香酊剂中25%鬼臼树脂的医院应用法（方案A）和自我应用法（方案B）治疗阴茎尖锐湿疣。目的是比较自我应用法与传统医院应用法的疗效和安全性。共选取了100名男性，其中64名可用于评估疗效。在六周的随访中，分别接受方案A和方案B治疗的患者治愈率分别为66%和72%。接受方案A治疗的患者依从性较差，仅完成了所需应用次数的58%，而接受方案B治疗的患者完成了92%。在成功治疗的患者中，接受方案A和方案B治疗的患者分别有43%和20%仅在一两次应用后就治愈了（p大于0.1）。三名患者——两名接受方案A治疗，一名接受方案B治疗——在首次应用鬼臼树脂后出现局部反应。所有这些患者均康复且无后遗症。因此，鬼臼树脂的自我应用在选定的阴茎尖锐湿疣男性患者中可以安全有效地使用。