六株牛分枝杆菌（卡介苗）对小鼠的毒力
Virulence of six strains of Mycobacterium bovis (BCG) in mice.
作者信息
Sher N A, Chaparas S D, Pearson J, Chirigos M
出版信息
Infect Immun. 1973 Nov;8(5):736-42. doi: 10.1128/iai.8.5.736-742.1973.
Abstract
The abilities of six strains of Mycobacterium bovis strain BCG to replicate in vivo and to cause spleen enlargement in the CDF(1) male mouse were compared. The strains were grown in synthetic medium and harvested soon after complete pellicles were produced on liquid medium. In addition, two freeze-dried commercially available preparations were tested. The comparisons were made on the basis of injecting equal numbers of colony-forming units. Strain differences were marked. The Brazil strain was most effective in stimulating spleen enlargement, and the Japan strain was the least effective. This correlated with the number of colony-forming units isolated from the spleen.
摘要
比较了六株卡介苗在CDF(1)雄性小鼠体内的复制能力以及导致脾脏肿大的能力。这些菌株在合成培养基中培养，在液体培养基上形成完整菌膜后不久收获。此外，还测试了两种市售冻干制剂。基于注射等量的菌落形成单位进行比较。菌株差异显著。巴西菌株在刺激脾脏肿大方面最有效，而日本菌株最无效。这与从脾脏中分离出的菌落形成单位数量相关。
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