Pine J H, Richter W R, Esterly J R
Am J Pathol. 1973 Oct;73(1):115-30.
Proteus infection in the rat produces an acute bacterial pneumonia which resolves without necrosis or significant organization within 2 weeks. Ultrastructural changes included widespread damage to type 2 cells and endothelial cells and rapid proliferation of the alveolar epithelial cells, which were the predominant site of labeling with tritiated thymidine. Histochemical staining for lysosomal enzymes showed an initial reduction in type 2 cell reactivity. The majority of proliferating epithelial cells were also unreactive until the normal pattern of staining and morphology returned at 8 to 12 days after infection. The acute inflammatory exudate was reactive, but there was only minimal to moderate staining in the subsequent clusters of alveolar macrophages. These data suggest that resolution with the preservation of the normal architecture of the peripheral airspaces may be correlated with superficial injury and limited reactivity for digestive enzymes.
大鼠感染变形杆菌会引发急性细菌性肺炎，该病在2周内可自行消退，不会出现坏死或显著的机化。超微结构变化包括2型细胞和内皮细胞广泛受损，以及肺泡上皮细胞迅速增殖，而肺泡上皮细胞是氚标记胸腺嘧啶核苷标记的主要部位。溶酶体酶的组织化学染色显示2型细胞反应性最初降低。大多数增殖的上皮细胞在感染后8至12天正常染色和形态恢复之前也无反应。急性炎性渗出物有反应，但随后的肺泡巨噬细胞簇中仅有轻度至中度染色。这些数据表明，外周气腔正常结构得以保留的消退可能与表面损伤和消化酶反应性有限有关。
