Yoneda K, Coonrod J D
Am J Pathol. 1980 Apr;99(1):231-42.
A self-healing lobar pneumonia was produced in rats by intratracheal instillation of Type 25 pneumococci. Sequential changes in the lung were examined by electron microscopy from the onset of acute inflammation through resolution. Manifestations of the infection included vascular endothelial changes of acute inflammation and leukocytic mobilization. The pulmonary alveolar epithelium showed only minimal changes throughout the infection. The significance of the findings is discussed in relation to the pathogenesis of pneumococcal lobar pneumonia.
通过气管内注入25型肺炎球菌在大鼠中制造出一种可自愈的大叶性肺炎。从急性炎症开始到消散，通过电子显微镜检查肺的连续变化。感染的表现包括急性炎症的血管内皮变化和白细胞动员。在整个感染过程中，肺泡上皮仅显示出轻微变化。结合肺炎球菌大叶性肺炎的发病机制对这些发现的意义进行了讨论。
