Jørgensen L, Grøthe A G, Groves H M, Kinlough-Rathbone R L, Richardson M, Mustard J F
McMaster University, Department of Pathology, Hamilton, Ontario, Canada.
Br J Exp Pathol. 1988 Jun;69(3):351-65.
To investigate the mechanisms involved in the cellular reactions to arterial injuries, we studied the distribution of the deposits on the injured intima and the pattern of neointimal thickening following single and double injuries of rabbit aortae with a balloon catheter. Thirty minutes after the first injury most, but not all, of the inner surface of the aortae was covered by adherent, spread platelets. Seven days following the first injury areas of neointima, mainly proliferating smooth muscle cells, had formed around and opposite the orifices of branch vessels. The rest of the inner aortic surface consisted of acellular subendothelial matrix. Thirty minutes after the second injury, 7 days after the first, single platelets adhered once more to parts of the reinjured subendothelium, mostly between the orifices. Numerous fibrin-rich, platelet thrombi were present mainly on the surface of the injured neointima. Thirty minutes after both the first and second injury polymorphonuclear leucocytes adhered to the inner surface downstream from the orifices of branch vessels and in longitudinally oriented zones opposite the orifices. Four days following the second injury, the neointima was restored with the same distribution as before the second injury, and few thrombi, adherent platelets, or leucocytes remained.
为了研究细胞对动脉损伤反应的相关机制，我们用球囊导管对兔主动脉进行单次和两次损伤，研究了损伤内膜上沉积物的分布以及新生内膜增厚的模式。首次损伤后30分钟，大部分（但不是全部）主动脉内表面被黏附、铺展的血小板覆盖。首次损伤后7天，新生内膜区域，主要是增殖的平滑肌细胞，在分支血管开口周围和相对处形成。主动脉内表面的其余部分由无细胞的内皮下基质组成。第二次损伤后30分钟，即首次损伤后7天，单个血小板再次黏附于再损伤的部分内皮下，主要在开口之间。大量富含纤维蛋白的血小板血栓主要出现在损伤的新生内膜表面。首次和第二次损伤后30分钟，多形核白细胞黏附于分支血管开口下游的内表面以及开口相对的纵向区域。第二次损伤后4天，新生内膜恢复到第二次损伤前的相同分布，残留的血栓、黏附的血小板或白细胞很少。
