大肠杆菌细胞内蛋白水解的严格控制。
Stringent control of intracellular proteolysis in Escherichia coli.
作者信息
Pine M J
出版信息
J Bacteriol. 1973 Dec;116(3):1253-7. doi: 10.1128/jb.116.3.1253-1257.1973.
Abstract
Regulation of intracellular proteolysis has been compared during amino acid deficiencies in seven double auxotrophs of Escherichia coli 9723f with a common phenylalanine requirement. Individual deficiencies were either more effective than, less effective, or equal to phenylalanine deficiency in stimulating intracellular proteolysis. For each amino acid, the same relationship prevailed in inhibiting uracil incorporation into nucleic acids, a reaction series regulated by the rel gene for stringent control. The three amino acids least abundant in the cellular protein were the least effective regulators. These findings are interpreted as supportive evidence for stringent control of intracellular proteolysis by the rel gene.
摘要
在七种对苯丙氨酸有共同需求的大肠杆菌9723f双营养缺陷型菌株中，对氨基酸缺乏期间的细胞内蛋白水解调节进行了比较。在刺激细胞内蛋白水解方面，个别氨基酸缺乏要么比苯丙氨酸缺乏更有效，要么效果较差，要么与之相当。对于每种氨基酸，在抑制尿嘧啶掺入核酸方面也存在相同的关系，核酸掺入反应系列受rel基因严格控制。细胞蛋白质中含量最少的三种氨基酸是最无效的调节因子。这些发现被解释为rel基因对细胞内蛋白水解进行严格控制的支持性证据。
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