大肠杆菌中氨基酸饥饿期间的多核糖体周转
Polysome turnover during amino acid starvation in Escherichia coli.
作者信息
Ron E Z
出版信息
J Bacteriol. 1971 Oct;108(1):263-8. doi: 10.1128/jb.108.1.263-268.1971.
Abstract
The experiments presented in this paper support earlier evidence that ribosomes are released from polysomes when they encounter a codon for which no charged transfer ribonucleic acid is available. However, it is further shown that these ribosomes then reinitiate and resume translation. The size and the level of polysomes during deprival of an amino acid is a function of the frequency with which that particular amino acid appears in cellular proteins. Polysomes from starved cells are more stable than those from growing cells, and, moreover, polysomes from starved relaxed strains are more stable than those from starved stringent strains.
摘要
本文所呈现的实验支持了早期的证据，即核糖体在遇到没有携带电荷的转运核糖核酸的密码子时会从多核糖体上释放出来。然而，进一步的研究表明，这些核糖体随后会重新起始并继续翻译。在缺乏某一种氨基酸的过程中，多核糖体的大小和水平是该特定氨基酸在细胞蛋白质中出现频率的函数。饥饿细胞中的多核糖体比生长细胞中的多核糖体更稳定，此外，饥饿松弛型菌株中的多核糖体比饥饿严谨型菌株中的多核糖体更稳定。
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本文引用的文献
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Increased stability of polysomes in an Escherichia coli mutant with relaxed control of RNA synthesis.在对RNA合成控制松弛的大肠杆菌突变体中多核糖体稳定性增加。
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