免疫反应抑制机制。I. 特异性抑制抗体对不同小鼠品系中51Cr标记的绵羊红细胞分布影响的差异。
Mechanisms of suppression of the immune response. I. Differences in the effect of specific inhibitory antibody on distribution of 51CR-labelled sheep erythrocytes in different mouse strains.
作者信息
Koros A M, Hamill E C
出版信息
Immunology. 1973 Oct;25(4):717-36.
The fate of Cr-labelled sheep red blood cells (SRBC) was studied in inbred AKR and outbred Swiss Webster mice given a single dose of specific anti-SRBC inhibitory antibody 24 hours before antigen. The amount of Cr in spleens of untreated mice in these two strains is the same, but the amount of Cr differs in spleens of antibody-treated AKR mice compared with antibody-treated Swiss Webster mice. Although there is increased uptake of Cr-labelled SRBC by spleens of AKR mice given anti-SRBC antibody, there is decreased uptake by spleens of Swiss Webster mice given the same antibody; nevertheless, the inhibitory effects of the anti-SRBC antibody assayed by anti-SRBC haemolytic plaque-forming cell (PFC) responses are similar in the two mouse strains. These results indicate that there is a mechanism other than a mere peripheral effect of anti-SRBC antibody in this system.
在给近交系AKR小鼠和远交系瑞士韦伯斯特小鼠注射抗原前24小时，给它们单剂量注射特异性抗绵羊红细胞（SRBC）抑制抗体，研究铬标记的SRBC的命运。这两种品系未处理小鼠脾脏中的铬含量相同，但与抗体处理的瑞士韦伯斯特小鼠相比，抗体处理的AKR小鼠脾脏中的铬含量有所不同。虽然给予抗SRBC抗体的AKR小鼠脾脏对铬标记的SRBC摄取增加，但给予相同抗体的瑞士韦伯斯特小鼠脾脏摄取减少；然而，通过抗SRBC溶血空斑形成细胞（PFC）反应检测的抗SRBC抗体的抑制作用在这两种小鼠品系中相似。这些结果表明，在该系统中，除了抗SRBC抗体的单纯外周效应外，还存在其他机制。
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