通过淋巴细胞转化试验研究抗体产生。I. CBA小鼠对绵羊红细胞的脾脏反应。
Antibody production studied by means of the LHG assay. I. The splenic response of CBA mice to sheep erythrocytes.
作者信息
Wortis H H, Taylor R B, Dresser D W
出版信息
Immunology. 1966 Dec;11(6):603-16.
Abstract
By means of a modified plaque assay the numbers of cells producing 19S antibody (direct PFC) and 7S antibody (developed PFC) have been studied separately. Significant and somewhat surprising differences in the responses of the two kinds of antibody-producing cell have been noted. It is clear that the route of injection of the antigen is of importance in determining the response in the spleen. The response of both types of PFC was found to be biphasic. The total increase in spleen cell number after immunization was not readily accounted for by the increase in specific PFC.
摘要
通过改良的空斑测定法，已分别研究了产生19S抗体的细胞（直接空斑形成细胞）和产生7S抗体的细胞（发育空斑形成细胞）的数量。已注意到两种产生抗体细胞的反应存在显著且有点令人惊讶的差异。显然，抗原的注射途径在决定脾脏反应方面很重要。发现两种类型的空斑形成细胞的反应都是双相的。免疫后脾细胞数量的总体增加不能简单地用特异性空斑形成细胞的增加来解释。
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[Effect of the thymus on the antibody production of mice cells, studied by the immunocytoadherence technic].[通过免疫细胞黏附技术研究胸腺对小鼠细胞抗体产生的影响]
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Cluster formation in vitro by mouse spleen cells and sheep erythrocytes.小鼠脾细胞与绵羊红细胞在体外形成集落。
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[Polymorphism of 19S antibody-producing splenic cells in mice].[小鼠中产生19S抗体的脾细胞的多态性]
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引用本文的文献
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Effect of beta-3-Thienylalanine on Antibody Synthesis IV. Suppression of the Immune Response in Mice.β-3-噻吩丙氨酸对抗体合成的影响 IV. 对小鼠免疫反应的抑制作用。
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Time Relationships Between Injection of Antigen and Adjuvant I. Adjuvancy of Bordetella pertussis Given at Various Times Before the Primary Antigenic Stimulus.抗原和佐剂注射时间的关系 I. 在初级抗原刺激之前的不同时间给予百日咳博德特氏菌作为佐剂的佐剂作用。
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Mycobacterial dose defines the Th1/Th2 nature of the immune response independently of whether immunization is administered by the intravenous, subcutaneous, or intradermal route.分枝杆菌剂量可独立于免疫接种是通过静脉内、皮下还是皮内途径进行，来决定免疫反应的Th1/Th2性质。
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Optimal strategies in immunology III. The IgM-IgG switch.免疫学中的最佳策略III. IgM向IgG的转换
J Math Biol. 1980 Nov;10(3):209-56. doi: 10.1007/BF00276984.
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Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune responses to a T-independent antigen.胸腺对非胸腺依赖性抗原的周期性独特型和相互抗独特型免疫反应的需求。
J Exp Med. 1980 Feb 1;151(2):289-300. doi: 10.1084/jem.151.2.289.
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Normal immunosuppressive protein: inhibitory effect on hemagglutinin and plaque formation as well as B cell transformation by Epstein-Barr virus.正常免疫抑制蛋白：对血凝素和蚀斑形成以及爱泼斯坦-巴尔病毒介导的B细胞转化具有抑制作用。
Experientia. 1982 Aug 15;38(8):963-5. doi: 10.1007/BF01953679.
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Requirement for continuous antigenic stimulation in the development and differentiation of antibody-forming cells. The effect of passive antibody on the primary and secondary response.抗体形成细胞发育和分化过程中对持续抗原刺激的需求。被动抗体对初次和二次反应的影响。
J Exp Med. 1969 May 1;129(5):953-71. doi: 10.1084/jem.129.5.953.
本文引用的文献
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STUDIES ON MOUSE ANTIBODIES. I. THE RESPONSE TO SHEEP RED CELLS.小鼠抗体研究。I. 对绵羊红细胞的反应。
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ANTIBODY SYNTHESIS AT THE CELLULAR LEVEL. ANTIBODY-INDUCED SUPPRESSION OF 19S AND 7S ANTIBODY RESPONSE.细胞水平的抗体合成。抗体对19S和7S抗体反应的抑制作用。
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THE MECHANISM OF TOLERANCE PRODUCED IN RATS TO SHEEP ERYTHROCYTES. I. PLAQUE-FORMING CELL AND ANTIBODY RESPONSE TO SINGLE AND MULTIPLE INJECTIONS OF ANTIGEN.大鼠对绵羊红细胞产生耐受性的机制。I. 对单次和多次注射抗原的噬斑形成细胞及抗体反应。
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IMMUNOGLOBULIN ISOANTIGENS (ALLOTYPES) IN THE MOUSE. I. GENETICS AND CROSS-REACTIONS OF THE 7S GAMMA-2A-ISOANTIGENS CONTROLLED BY ALLELES AT THE IG-1 LOCUS.小鼠中的免疫球蛋白同种抗原（别型）。I. 由Ig-1位点等位基因控制的7Sγ-2A同种抗原的遗传学及交叉反应。
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THE NATURE OF ANTIBODIES FOLLOWING EXPERIMENTAL ARBOVIRUS INFECTION IN GUINEA PIGS.豚鼠实验性虫媒病毒感染后抗体的性质
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ESTIMATION OF THE INDUCTIVE PHASE OF ANTIBODY FORMATION BY PLAQUE TECHNIQUE.用蚀斑技术估计抗体形成的诱导期
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APPLICATION OF A LOCALIZED HEMOLYSIN REACTION FOR SPECIFIC DETECTION OF INDIVIDUAL ANTIBODY-FORMING CELLS.局部溶血素反应在个体抗体形成细胞特异性检测中的应用。
J Exp Med. 1964 Apr 1;119(4):667-84. doi: 10.1084/jem.119.4.667.
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Effectiveness of lipid and lipidophilic substances as adjuvants.脂质和亲脂性物质作为佐剂的有效性。
Nature. 1961 Sep 16;191:1169-71. doi: 10.1038/1911169a0.
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Phagocytosis of foreign red blood cells by the reticulo-endothelial system.网状内皮系统对外来红细胞的吞噬作用。
Am J Physiol. 1957 Jun;189(3):520-6. doi: 10.1152/ajplegacy.1957.189.3.520.
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Separation of 7S gamma-1-globulin, 7S gamma-2-globulin and macroglobulin guinea pig antibodies.7Sγ-1球蛋白、7Sγ-2球蛋白和豚鼠巨球蛋白抗体的分离
Proc Soc Exp Biol Med. 1966 Feb;121(2):508-14. doi: 10.3181/00379727-121-30817.
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