免疫反应的调节。VI. F(ab')₂抗体无法终止已建立的免疫反应及其干扰IgG抗体介导的免疫抑制的能力。
Regulation of the immune response. VI. Inability of F(ab') 2 antibody to terminate established immune responses and its ability to interfere with IgG antibody-mediated immunosuppression.
作者信息
Chan P L, Sinclair N R
出版信息
Immunology. 1973 Feb;24(2):289-301.
Abstract
Intact IgG antibody can terminate established immune responses, whereas F(ab′) antibody cannot do so. The difference between the two antibodies appears to be qualitative. F(ab′) antibody, but not pepsin-digested normal serum, can interfere with the suppression and termination of immune responses induced by intact IgG antibody. These results are discussed in terms of the tripartite inactivation model.
摘要
完整的IgG抗体可终止已建立的免疫反应，而F(ab′)抗体则不能。这两种抗体之间的差异似乎是质性的。F(ab′)抗体而非经胃蛋白酶消化的正常血清，可干扰由完整IgG抗体诱导的免疫反应的抑制和终止。根据三方失活模型对这些结果进行了讨论。
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