原位肝移植后“肝肾综合征”的恢复
Recovery from "hepatorenal syndrome" after orthotopic liver transplantation.
作者信息
Iwatsuki S, Popovtzer M M, Corman J L, Ishikawa M, Putnam C W, Katz F H, Starzl T E
出版信息
N Engl J Med. 1973 Nov 29;289(22):1155-9. doi: 10.1056/NEJM197311292892201.
Abstract
Three patients with progressive renal failure and advanced hepatic insufficiency due to cirrhosis of the liver underwent orthotopic liver transplantation. All three patients had immediate improvement in hepatic function and within two weeks after liver replacement regained nearly normal kidney function. However, the renal recovery was delayed in each case, and its course was not uniform. Plasma renin activity was high, and renin substrate was low before transplantation in one case in which these measurements were obtained; both returned to normal soon after liver replacement.
摘要
三名因肝硬化导致进行性肾衰竭和晚期肝功能不全的患者接受了原位肝移植。所有三名患者的肝功能立即得到改善，在肝脏置换术后两周内肾功能恢复到几乎正常。然而，每个病例的肾功能恢复都延迟了，而且过程并不一致。在其中一例进行了这些测量的患者中，移植前血浆肾素活性高，肾素底物低；肝脏置换后不久两者均恢复正常。
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