Mage R G
Fed Proc. 1975 Jan;34(1):40-6.
Genetically controlled intraspecific differences between immunoglobulins (allotypes) provide valuable markers for the study of the quantitative expression of allelic and nonallelic alternative forms of immunoglobulins (Igs) during the normal development of rabbits. Heterozygous rabbits are mosaics of cells expressing different Ig-genes since fully differentiated productive cells generally secrete only one of alternative forms of Ig. The proportions of cells that differentiate to produce allelic forms of immunoglobulins during normal development depend on the particular heterozygous genotype. The normal proportions of some markers can be drastically altered if the differentiation of lymphoid cells in the young rabbit occurs in the milieu of antibody specific for one form (allotype suppression). An initiating step in the establishment of persistent allotype suppression is probably the interaction of antiallotype antibody with allotype-bearing receptors on lymphoid cell surfaces, but the mechanism for the maintenance of a state of chronic suppression may well be more complex. Allotype suppression can be viewed as one example of numerous immunological phenomena that reflect specific and finely tuned regulatory mechanisms governing the differentiation and clonal expansion of lymphoid cells destined to secrete immunoglobulins.
免疫球蛋白（同种异型）之间的遗传控制种内差异为研究家兔正常发育过程中免疫球蛋白（Ig）等位基因和非等位替代形式的定量表达提供了有价值的标记。杂合家兔是表达不同Ig基因的细胞镶嵌体，因为完全分化的产生性细胞通常仅分泌Ig替代形式之一。在正常发育过程中分化产生免疫球蛋白等位形式的细胞比例取决于特定的杂合基因型。如果幼兔淋巴细胞的分化发生在针对一种形式（同种异型抑制）的抗体环境中，一些标记的正常比例可能会发生巨大改变。建立持续性同种异型抑制的起始步骤可能是抗同种异型抗体与淋巴细胞表面携带同种异型的受体相互作用，但维持慢性抑制状态的机制可能更为复杂。同种异型抑制可被视为众多免疫现象的一个例子，这些现象反映了控制注定要分泌免疫球蛋白的淋巴细胞分化和克隆扩增的特定且精细调节的调控机制。
