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成年小鼠过继转移系统中的同种异型抑制：单克隆IgG3抗-（Igh-1b）同种异型抗体的特异性及反馈效应

Allotype suppression in an adoptive transfer system in adult mice: the specificity and feedback effects of a monoclonal IgG3 anti-(Igh-1b) allotype antibody.

作者信息

Curling E M, Dresser D W

出版信息

Immunology. 1984 Mar;51(3):511-6.

PMID:6365744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454460/
Abstract

Using an adoptive transfer system in mice, an allotype-specific suppression has been induced by a monoclonal IgG3 anti-Igh-1b (Hyb 5.7) reagent. Suppression was specific for IgG2a (Igh-1b) and led to a compensatory increase of the Igh-1a response in irradiated mice reconstituted with allotype heterozygous (Igha/b) spleen cells. Suppression, which was not antigen-specific, lasted for at least 1 month after anti-allotype treatment.

摘要

在小鼠中使用过继转移系统，一种单克隆IgG3抗-Igh-1b（Hyb 5.7）试剂诱导了同种异型特异性抑制。这种抑制对IgG2a（Igh-1b）具有特异性，并导致在用同种异型杂合（Igha/b）脾细胞重建的辐照小鼠中Igh-1a反应的代偿性增加。这种抑制不是抗原特异性的，在抗同种异型治疗后至少持续1个月。

相似文献

1
Allotype suppression in an adoptive transfer system in adult mice: the specificity and feedback effects of a monoclonal IgG3 anti-(Igh-1b) allotype antibody.成年小鼠过继转移系统中的同种异型抑制：单克隆IgG3抗-（Igh-1b）同种异型抗体的特异性及反馈效应
Immunology. 1984 Mar;51(3):511-6.
2
Antibody-mediated allotype suppression in adult mice: the role of antigen, effector isotype and regulatory T cells.成年小鼠中抗体介导的同种异型抑制：抗原、效应亚型和调节性T细胞的作用。
Eur J Immunol. 1984 Oct;14(10):865-70. doi: 10.1002/eji.1830141002.
3
Generation in vivo of non-T suppressor cells with the use of anti-allotype antibody.利用抗同种异型抗体在体内产生非T抑制细胞。
J Immunol. 1988 Jan 1;140(1):15-20.
4
Igh-1b-specific CD4+CD8- T cell clones of the Th1 subset selectively suppress the Igh-1b allotype in vivo.Th1亚群的Igh-1b特异性CD4+CD8-T细胞克隆在体内选择性抑制Igh-1b同种异型。
Eur J Immunol. 1991 Oct;21(10):2365-71. doi: 10.1002/eji.1830211011.
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T cell-induced Ig allotypic suppression in mice. II. Both CD4+ CD8- and CD4- CD8+ T cell subsets from sensitized Igha mice are required to induce suppression of Igh-1b allotype expression.小鼠中T细胞诱导的Ig同种异型抑制。II. 致敏的Igha小鼠的CD4+ CD8-和CD4- CD8+ T细胞亚群均需要诱导Igh-1b同种异型表达的抑制。
J Immunol. 1989 Jan 1;142(1):1-7.
6
Enhancement in Igha mouse strains of the "natural" suppressive activity of normal T splenocytes against the expression of Igh-1b allotype. I. Molecular aspects of the chronic suppression obtained.Igha小鼠品系中正常T脾细胞对Igh-1b同种异型表达的“天然”抑制活性增强。I. 所获得的慢性抑制的分子层面。
Eur J Immunol. 1988 Jan;18(1):51-8. doi: 10.1002/eji.1830180109.
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Mechanisms of mouse T lymphocyte-induced suppression of the IgG2ab allotype and T lymphocyte tolerance to IgG2ab.小鼠T淋巴细胞诱导IgG2ab同种异型抑制及T淋巴细胞对IgG2ab耐受的机制。
Arch Immunol Ther Exp (Warsz). 2001;49(6):407-15.
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Allotype suppression induced in the adoptive transfer system: the variables of the system and an apparent absence of a role for T cells.过继转移系统中诱导的同种异型抑制：系统变量及T细胞作用的明显缺失
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Allotype suppression of the responsiveness of adoptively transferred adult spleen cells induced by affinity prepared anti-allotype antibody.亲和制备的抗同种异型抗体诱导的过继转移成年脾细胞反应性的同种异型抑制。
Immunology. 1981 Apr;42(4):601-10.
10
Heterogeneity of Igh-linked allotypic determinants expressed on functional T cell subsets as detected by monoclonal antibodies.通过单克隆抗体检测功能性T细胞亚群上表达的Igh连锁同种异型决定簇的异质性。
Eur J Immunol. 1984 May;14(5):413-20. doi: 10.1002/eji.1830140506.

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Allotype suppression of the responsiveness of adoptively transferred adult spleen cells induced by affinity prepared anti-allotype antibody.亲和制备的抗同种异型抗体诱导的过继转移成年脾细胞反应性的同种异型抑制。
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Allotype suppression induced in the adoptive transfer system: the variables of the system and an apparent absence of a role for T cells.过继转移系统中诱导的同种异型抑制：系统变量及T细胞作用的明显缺失
Immunology. 1981 Apr;42(4):611-8.
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